Oncology
The Surgery Department at St James’s Hospital, has a long established research program. We run a number of both investigator-led and industry centred drug trials. We have new form of cancer treatment called CAR T-cell therapy is now available to patients with lymphoma. Called ‘chimeric antigen receptor’ (CAR) T-cell therapy, this treatment uses the patient’s own immune cells to fight their cancer.
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| Cartitude | A Phase 3 Randomized Study Comparing Bortezomib, Lenalidomide and Dexamethasone (VRd) followed by Ciltacabtagene, Autoleucel, a Chimeric Antigen Receptor T cell (CAR-T) Therapy directed Against BCMA versus Bortezomib, Lenalidomide, and Dexamethasone (VRd) followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants with newly diagnosed Multiple Myeloma for Whom Hematopoietic Stem Cell Transplant is not Planned as initial therapy | Clinical trial (NCT04923893) (2021-001242-35) | Janssen | Commercial: Industry |
| Cares | A Phase 1/2 Trial of the Synthetic Cannabinoid ART27.13in Patients with Cancer Anorexia and Weight Loss | Clinical trial (2020-000464-27) | Artelo Biosciences Limited | Commercial: Industry |
| DASL-HiCAP | Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate (ANZUP1801). A randomised phase 3 double-blind, placebo-controlled trial of adding darolutamide to androgen deprivation therapy and definitive or salvage radiation in very high risk, clinically localised prostate cancer. | Clinical Trial (NCT04136353) | ANZUP | Charity |
| t-BRCA | Upfront systematic tumour BRCA testing in patients with high grade serious or endometrioid ovarian, fallopian tube or primary peritoneal cancer: The t-BRCA Study | Observational with invasive tests | AstraZeneca | Industry |
| PERCS Study | Personalised Exercise Rehabilitation in Cancer Survivorship: The PERCS Programme | Observational-non invasive | Irish cancer society | Charity |
| Liquid Biopsies in Cancer | Liquid Biopsy in Cancer Predisposition | Observational with invasive tests | N/A | Charity |
| SARONG-II | Open label international multicentre randomised controlled trial of intensive surveillance vs. standard postoperative follow-up in patients undergoing surgical resection for oesophageal and gastric cancer | Clinical trial | Irish Cancer Society | Charity |
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| IPCOR | Irish Prostate Cancer Outcomes Research | Observational-non invasive | Irish Cancer Society & Movember | Charity |
| Barrett's Oesophaegus | Barrret's Oesophagus Registry: Registry of Irish Patient's with Barrett's and Barrett's Oesophagus | N/A | Academic | |
| Neo-AEGIS | Randomised clinical trial in adenocarcinoma of the oesophagus and oesophago-gastric junction: A comparison of neo-adjuvant and adjuvant chemotherapy and surgery versus neo-adjuvant chemoradiation and surgery | Clinical Trial | St James’s hospital | Academic |
| Gut Hormones after upper GI surgery | Food intake and gut hormones release in patients in cancer remission who have undergone upper gastrointestinal surgery | Observational with radiology or blood tests | N/A | Academic |
| Upper GI Biobank | Delineation of the regulatory networks in upper gastrointestinal cancers using a genome-wide approach | Observational with radiology or blood tests | N/A | Academic |
| MAGIC | Randomised trial in adenocarcinoma of the oesophagus and oesophago-gastric junction: A comparison of neo-adjuvant and adjuvant chemotherapy and surgery versus neo-adjuvant chemoradiation and surgery (MAGIC) | Clinical trial (NCT01726452) | HSE/HRB | Non-commercial: Academic |
| PREPARE | PREPARE - Preoperative inspiratory muscle training to prevent postoperative pneumonia in patients undergoing esophageal resection | Observational-non invasive | N/A | Academic |
| Satiety GH Modulation on Appetite | The effect of satiety gut hormone modulation on appetitive drive after upper gastrointestinal surgery | Nutritional Trial | N/A | Academic |
| Longitudinal assessment of gut hormone | Longitudinal assessment of gut hormone secretion following upper gastrointestinal surgery for cancer | Observational with radiology or blood tests | N/A | Academic |
| TRANSIT | Characterisation of changes in nutrient handling after upper gastrointestinal surgery - TRANSIT | Observational | N/A | Non Commercial: Academic |