Intensive Care
St James’s hospital has the largest Intensive Care Unit capacity in Ireland. The CRF in conjunction with the intensive care unit manages both investigator led studies and clinical trials.
Dr Ignacio Martin-Leoches is particularly interested in sepsis and researching how best to treat this in an acute ICU setting.
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| The Sepsis Study | Developing a hybrid evolvable disease sensor for sepsis | Observational with radiology or blood tests | St. James's hospital | National (Government agency) |
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| Revival Trial | A Randomized, Double-Blind, Placebo-Controlled, Two-Arm Parallel-Group, Multi-Center Phase 3 Pivotal Trial to Investigate the Efficacy and Safety of Recombinant Human Alkaline Phosphatase for Treatment of Patients with Sepsis Associated Acute Kidney Injury | Clinical trial (NCT04411472) | AM-Pharma B.V. | Commercial: Industry |
| CUBIST | A prospective randomised double blind multicentre phase 3 study to assess the safety and efficacy of IV ceftolozane/tazobactram compared to meropenem in adult patients with ventilated nosocomial pneumonia | Clinical trial (NCT02070757) | Cubist Pharmaceuticals | Industry |
| EVADE | A Phase 2 Proof-of-concept Study to Evaluate the Efficacy and Safety of MEDI3902 in Mechanically Ventilated Patients for the Prevention of Nosocomial Pneumonia Caused by Pseudomonas aeruginosa | Clinical trial (NCT02696902) | Medimmune | Industry |
| TAME | Targeted therapeutic mild hypercapnia after resusictated cardiac arrest: A phase III multi-centre randomized controlled trial | Clinical trial (NCT03114033) | ANZIC | Non commercial |
| SPICE III | A Prospective Multicentre RCT of Early Goal Directed Sedation Compared with Standard Care in Mechanically Ventilated Patients in Intensive Care | Other (NCT01728558) | ANZIC | Non-commercial |
| Transfuse | Standard issue transfusion versus fresher red blood cell use in intensive care - a randomized controlled trial | Observational with invasive tests (NCT01638416) | ANZIC | Non-commercial |